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fludrocortisone will reduce the extent or effect of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.Keep track of Closely (one)mitotane decreases levels of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check. Mitotane is a solid inducer of cytochrome P-4503A4; check when co